Math Jokes

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Calculating limit

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Solving Equation by Blondie

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Laloo Prasad Yadav applies to Microsoft

Laloo Prasad sent his Bio Data – to apply for a post in Microsoft Corporation, USA.
A few days later he got this reply:

Dear Mr. Laloo Prasad,
You do not meet our requirements. Please do not send any further correspondence.
No phone call shall be entertained.

Thanks
Bill Gates.


Laloo prasad jumped with joy on receiving this reply.
He arranged a press conference : “Bhaiyon aur Behno, aap ko jaan kar khushi hogee ki hum ko Amereeca mein naukri mil gayee hai.”
Everyone was delighted. Laloo prasad continued…… “Ab hum aap sab ko apnaa appointment Letter padkar sunaongaa ? par letter angreeze main hai – isliyen saath-saath Hindi main translate bhee karoonga.


Dear Mr. Laloo Prasad —– Pyare Laloo prasad bhaiyya
You do not meet —–aap to miltay hee naheen ho
our requirement —– humko to zaroorat hai
Please do not send any furthur correspondance —– ab Letter vetter bhejne ka kaouno zaroorat nahee.
No phone call —– phoonwa ka bhee zaroorat nahee hai
shall be entertained —– bahut khaatir kee jayegi.

Thanks —– aapkaa bahut bahut dhanyavad.
Bill Gates. —- Tohar Bilva.
.

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‘Eternal Sunshine’ drug selectively erases memories

http://www.newscientist.com/article/dn15025-eternal-sunshine-drug-selectively-erases-memories.html
http://www.cell.com/neuron/retrieve/pii/S089662730800768X

For those haunted by thoughts of an old flame or a tragic accident, the chance to selectively erase memories might be tempting.

Now scientists have moved a step closer to that possibility by wiping away a month-old memory in genetically engineered laboratory mice, while leaving other memories unchanged.

The researchers boosted levels of a protein called α-CaMKII involved in memory storage and retrieval, just as mice recalled the pain of receiving a light shock. This had the effect of dispelling the memory.

“I don’t think it’s possible to use our method in humans, whether it’s now or in the future,” says Joe Tsien, a neuroscientist at the Medical College of Georgia in Augusta. “But it does suggest that perhaps you can look into downstream targets [of α-CaMKII]. Maybe some pharmaceutical company is looking at that.”

Shattered belief

Tsien’s experiments aren’t the first to raise the prospect of selective memory erasure.

Several years ago, researchers showed that injecting mice with a drug that stops new proteins from forming can block an old memory as it is recalled.

And last year, another team found that inhibiting a specific protein can erase old memories, even without recalling them.

These experiments have helped shatter the century-old belief that memories are an indelible anatomical feature of the brain, says neuroscientist Todd Sacktor, of SUNY Downstate Medical Center in Brooklyn, New York. Rather, memories are the stuff of molecular connections, constantly built and destroyed by specific enzymes.

“There are actually key molecules that have specific role in long-term memory,” he says. “It’s a real big shift in thinking.”

Shock treatment

Based on previous experiments that showed that α-CaMKII was important to a cellular phenomenon thought to underlie memory formation, Tsien’s team bred mice engineered to make extra levels of the enzyme. His team could return their α-CaMKII levels to normal by giving the mice a drug that blocked only the engineered copy.

To test the effect of the change, Tsien and colleagues at the East China Normal University in Shanghai gave mice a slight shock in a training chamber while playing a loud tone.

With thoughts of a jolt fresh in their brain, mice with normal levels of α-CaMKII froze up when they returned to the chamber an hour later, while mice with boosted levels remained calm.

Even a month after the shock – enough time for mice to store the memory for good – cranking up α-CaMKII eroded all memories of the shock treatment, Tsien’s team found.

The memory also seemed completely lost, not temporarily unavailable. Six weeks after the initial conditioning and two weeks after the initial erasure, engineered mice treated so they expressed normal levels of α-CaMKII could not retrieve memories of the shock.

Value of recall

Tsien’s team is still trying to explain how turning up a single protein can erase specific memories, but he thinks the protein weakens brain cell connections that were built up when the memory was first made.

“This paper is a real revolution in how we think about long term memory,” says Sacktor, who last year showed that blocking an enzyme called PKM-zeta erases long-term memories in rats, while leaving their ability to form new ones unchanged. It is not yet clear which route to memory removal will prove most useful in humans, he says.

Tsien, however, cautions against applying his team’s results to expunging thoughts of broken hearts or limbs. “All memories, even very painful emotional memories, have their purposes. We learn from those experiences to avoid making the same kind of mistake.”

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Disneyworld trip

best vacation to date.
7/8: sea->mco. arrived at pop century resort. amazing! visited animal kingdom lodge. amazing!
7/9: magic kingdom. splash mountain & space mountain were best rides. evening parade, its a small world, winnie the pooh, photos w/ characters
7/10: discovery cove. perhaps the highlight of this trip. unforgettable experience.
7/11: hollywood studios. hollywood tower ride was just too good. fantasmic – great show. beauty & the beast. car chase. indiana jones.
7/12: animal kingdom. mt. everest & kali rapids were the best rides. enjoyed jungle safari. finding nemo.
7/13: seaworld. manta, kraken, journey to atlantis. unforgettable shamu shows.
7/14: back to sea
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Experimental Evidence of Quantum Randomness Incomputability

In contrast with software-generated randomness (called pseudo-randomness), quantum randomness is provable incomputable, i.e. it is not exactly reproducible by any algorithm. We provide evidence of incomputability – an asymptotic property – of quantum randomness by performing finite tests of randomness inspired by algorithmic information theory.
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How to give your boss feedback

Working closely with anyone gives you useful insight into her performance. This is especially true of your boss, who you likely see in a variety of settings: client meetings, presentations, one-on-ones, negotiations, etc. But even if that insight could be helpful to your boss, is it your place to share it with her? Could you be putting your job or your relationship at risk by telling her what you see or by giving her frank feedback? Giving your boss feedback, commonly called upward feedback, can be a tricky process to master. However, if offered correctly and thoughtfully, your insight can not only help your boss, but also improve your working relationship.

What the Experts Say
John Baldoni, a leadership consultant, coach, and author of Lead Your Boss: The Subtle Art of Managing Up says that leadership is all about perception; if leaders do not know how they are perceived, their performance will suffer. However, the higher up in an organization a leader sits, the harder it is to get honest feedback. James Detert, Assistant Professor at the Cornell Johnson Graduate School of Management and author of the Harvard Business Review article "Why Employees Are Afraid to Speak" and "Speaking Up to Higher-Ups: How Supervisors and Skip-Level Leaders Influence Employee Voice" says, "Over reliance on the chain of command prevents leaders from hearing the unvarnished truth." Your input can help your boss see herself as others see her and help her to make critical adjustments in her behavior and approach. However, giving this type of feedback requires careful thought; here are some principles to keep in mind.

The relationship comes first
The ability to give and receive upward feedback, like any form of feedback, is dependent on the relationship between you and your boss. Without trust, the feedback will be impossible to receive. Before giving feedback, you need to gauge whether your boss will be open to what you have to say. If you know that your boss is unreceptive to feedback, is likely to react negatively, or if you have a rocky relationship, it’s better not to say anything. However, as Baldoni points out, "If your boss is open-minded and you have a good relationship, you owe him the straight talk." As with any feedback, your intentions must be good and your desire to help your boss should supersede any issues you may have between you.

Wait to be invited, or ask to be invited?
Even if you have a great relationship, launching into unsolicited feedback is ill-advised. As Detert says, "General advice on how to be a better boss is tough to give unless you’re asked for it." Ideally, your boss has asked for your input and made clear what would be helpful to her in terms of feedback. Your boss may disclose her development areas and ask you to keep an eye out for certain behaviors that she is working on. Baldoni says, "In a perfect world, it is a manager’s responsibility to make it safe to give feedback."

However, Baldoni acknowledges that in the real world this may not always happen. If your boss does not directly request feedback, you can ask if she would like feedback. This is often most easily done in the context of a new project or new client. You can say something like "Would it be helpful to you for me to give you feedback at certain points in this project?" or "I’m likely to have a unique perspective on what we’re doing, would you like some feedback about how the project is going?" Again, these questions must be presented with the best of intentions. Since it is her job to give you feedback, avoid sounding like you want to give feedback in a vengeful way. Demonstrate your willingness to help her improve.

Focus on your perspective
It can be tempting when your boss is open to feedback, to imagine all the things you would do if you were in his position. However, your feedback should focus on what you are seeing or hearing, not what you would do as the boss. Baldoni recommends that you "frame feedback in form of your perceptions." He suggests saying things such as "I noticed at that meeting that you came across as bullying." By sharing your perspective you can help your boss to see how others are seeing him. This can be invaluable to a leader who may be disconnected from people in the lower ranks.

Focusing on your view also means realizing the limitations of your standpoint. You need to remember that you are seeing only a partial picture of your boss’s performance and you may not appreciate or realize the demands on him. Detert says, "Subordinates by and large don’t have a full appreciation of the reality of their bosses." Give feedback that is reflective of what you can see and avoid presuming what he is faced with. Remember that good feedback rules still apply. Your feedback should be honest and data-driven. Open with affirmative feedback and give constructive feedback with suggestions for improvement. Avoid accusations. "People react much, much better to specifics than to generalities," Detert says. So use details to back up your points.

When your boss bites back
No matter how carefully or thoughtfully you’ve prepared and delivered your feedback, your boss may get upset or be defensive about the feedback you’ve given. If you were asked for the feedback, Baldoni says you should hold your ground and explain that you were doing what was asked of you. Sometimes reframing the feedback can help. Detert urges that feedback is more easily received if you "frame it in terms of what your boss cares about." He says, "You can point out specific ways that specific behaviors are inhibiting the boss from achieving his goals."

Gauge her reaction to determine how she likes to receive feedback and what topics are out of bounds. Perhaps she doesn’t want to hear feedback about her communication style or a certain high-pressure initiative. Rather than clamming up after a negative reaction, take the opportunity to check in with her about what would be useful going forward.

When in doubt, hold your tongue
If you’re not sure if your boss wants to hear feedback or if the subject of the feedback is a sensitive one, it’s almost always better to not speak up. There is no reason to risk your working relationship or your job, unless you feel your boss’s behavior is putting the company or your unit in jeopardy. Instead, look for opportunities to give anonymous feedback, such as a 360 degree feedback process.

Principles to Remember
Do:

  • Be certain your boss is open and receptive to feedback before speaking up
  • Share with her what you are seeing and hearing in her organization or unit
  • Focus on how you can help her improve, not on what you would do if you were boss

Don’t:

  • Assume your boss doesn’t want feedback if she doesn’t request it — ask if she would like to hear your insight
  • Presume you know or appreciate your boss’s full situation
  • Give feedback as way to get back at your boss for giving you negative feedback

Case Study #1: Giving feedback by asking for it first
Wendy Wise worked for the Strategic Pricing Group, a small, growing consulting group. It was a fast-paced culture, in which people were often stretched and expectations were high. Because of the rapid growth, people were promoted quickly and expected to be able to do a job right away. Wendy was put on a team under Simon, a recently promoted manager. He was doing a great job but didn’t have any formal managerial experience or training. Wendy knew that Simon would be thrust into situations in which he would have to adeptly manage clients and teams of consultants. Because of her tenure with the organization, she had more experience in these areas and she knew her job would be easier if Simon had the help he needed. Wendy said, "I asked myself ‘How can I find a way to help him without threatening him?’" She decided to start by sitting down with him, explaining to him the things she had been working on and asking if he would watch out for those things and give her feedback. Then she said, "Your boss doesn’t see what you do every day, but I do. I know you’re doing a lot of presenting, for example, and I’d be happy to give you feedback if you’d find that useful." Simon was relieved that he didn’t have to pretend that he was infallible and that he could rely on Wendy for frank feedback. As their working relationship developed, they each added things to the list that they wanted the other to look out for. Wendy said, "I think we helped each other be successful in the organization." Strategic Pricing Group has since been sold and both Wendy and Simon have moved on to other jobs, but they continue to reach out to each other for advice and mentoring.

Case Study #2: Being a voice for the organization
Shortly after Gerard van Grinsven became the CEO of Henry Ford Health Systems, a 300-bed hospital in Michigan with 1,300 employees, he hired a former colleague, Sven Gierlinger to be the Administrator of Hospitality Services. Sven and Gerard had worked together at Ritz Carlton and shared a passion for service. Because of their prior working relationship, Gerard often relied on Sven to share what he was hearing and seeing throughout the organization.

A few years back, Gerard restructured a department that needed better results. Because of the changes, there was some understandable grumbling in the department. Gerard is an effective communicator, especially in stressful times. He pulled the entire unit together and asked that the grumbling stop and the employees focus on making the new structure work and improving their results. However, the employees left the meeting unhappy. Gerard turned to Sven and asked for his objective assessment: what would he have done in that situation? Sven could have easily appeased Gerard and said "you did the right thing" but he had heard from several of the meeting attendees that it had not gone well. He was honest with Gerard, shared what he heard, and explained what he would’ve done differently. Sven said, "I was able to give him that feedback because he trusted me. If the trust is not there, the feedback can be misconstrued." Gerard thanked him for his honesty and set about repairing the damage done in the meeting.

At leadership meeting shortly after, Gerard talked about the feedback he received and explained to his team how he changed his behavior based on the input. This reinforced Sven’s perception of Gerard as a leader who not only welcomes feedback, but makes use of it.

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does us produce too many scientists

 
Whatever model or models the nation chooses, many observers believe that the existing system of research by professors who constantly produce large numbers of scientists unlikely to achieve their career aspirations is near collapse. The real crisis in American science education is not young Americans’ inability to learn, or the schools’ inability to teach, but a distorted job market’s inability to provide them careers worthy of their abilities.
 
ludz13 at 09:17 AM on 02/23/10
The professional sports analogy is very apt. Academia really has become a huge competition with very few winners reaping all the spoils (academic jobs), while the majority of competitors  toil away in the minor leagues (as post-docs, etc…) until they eventually give up and go do something else once they give up that dream.

Most people who pursue PhDs do want to become professors, at least for a while, despite any protests to the contrary. PhD degrees are like viruses: The only thing they are good for are making more PhDs. In part, this also represents a failure of our graduate education system, which only prepares students for careers in academic research.

As a PhD graduate of a major American research University, with, as a result, many PhD friends, I really do not know a single person who finished their degree in the last 15 years and who would recommend getting a PhD. Even those of us lucky enough to have attained some measure of academic success recognize how brutal

and unworkable the process has become. I almost feel guilty helping to recruit new graduate students. And I never recommend to even the brightest undergraduates
 that they pursue a research career. My wife (also a PhD) and I often joke that our kids can grew up to be whatever they want–except PhDs.
I think the article overstates how much better the situation is elsewhere. Good jobs are still sparse; the ultimate goal is the rare and coveted independent research position, which very few people attain anywhere.
 
eekm at 03:29 PM on 02/24/10
Great, well researched article.  As a recent PhD in biochemistry, I can tell you this is right on the mark.  I went to one of the top research schools for my PhD and the success rate coming out of the PhD program was ~1/20 landing a tenure track research faculty position (after 5-10 more years of postdocing).  Most of us thought we would be profs when we entered (we were all heavily recruited by multiple top schools.  How could there be so few jobs at the end?)  After many years as slave-labor PhDs and postdocs, many have left science and found other careers.  Why would the smartest kids in America stick around making $37k a year with no benefits or job security when their friends are making much better money in more stable careers.  It would just be dumb to continue to be slave labor.  The article is right on in pointing out that non-Americans have the incentive of using this as a ticket into the U.S.  Many of my non-American science friends have married Americans or gotten permanant green card status and stayed.  It really has been their ticket, so it didn’t matter as much to them to spend their 20s and 30s being slave labor.  But spending 10-15 years as slave labor (while friends are building their careers, buying houses, getting married) matters to most bright, highly trained American kids, so many of us end up leaving science.  It is a terrible system that perpetuates the myth of scientist shortages.  Teaching more people to understand science (which does need to be done) is not the same as saying their are scientists shortages.  To make that connection would be as silly as blaming illiteracy on lack of novelists (rather than a lack of good reading teachers and parental input). 
 

sdanzi at 12:03 PM on 02/24/10

Absolutely true. I loved this article. When students ask me if they should pursue a graduate degree and career in science I tell them if they have to ask, they shouldn't do it. It's just not a good job and there is no security. You only do it because you love science. I have never known a scientist who doesn't love what he/she does.

 

Taq at 09:46 PM on 03/03/10

I am currently working as a post-doc at one of the ivy league schools. I am a foreign national who came to this country to do PhD in biological sciences. If I had read this article during my undergradute degree, I would have refrained from getting a PhD. Life is too short to get economic and job security at the age of 45. Most of my friends with Bachelor's degree in engineering make around 100K , whereas as a postdoc, I have to struggle with bare minimum (37-40 k), put in the slave labor and suck up to miserable bosses. Being international postdoc is more tough because visa status is tied to the employment, making postdocs more vulnerable to exploitation. This is the main reasons international national postdocs are preffered, as most of them will not stand up for themselves. American postdocs will not tolerate such exploitation as they have alternative career options. After postdoc it is also difficult for international postdocs to establish themselves as faculty members  if they have language based communication issues . They  also have a very few choices in getting   positions in biotech/pharma industries and and govt jobs which are mostly restricted to citizens or permanent residents. International postdocs are underpaid, overworked and exploited intellectuals whose dream of american dream mostly remains a dream...

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To rebalance or not to rebalance

I have not been able to understand the concept of rebalancing in investing. To me its a form of the gambler’s fallacy. Let:
s_n = stock price at time n
s_{n+1} = stock price at time n+1
Then, if E[s_{n+1}|s_n=c] = c, in my opinion rebalancing does not make any sense
However, if E[s_{n+1}|s_n=c] = E[s_{n+1}] = E[s_n] = k, then rebalancing totally makes sense
Notes:
1. Case 1 is a random walk, case 2 isn’t
2. Case 2 is what I understand as reversion/regression to mean
 
Comments and thoughts welcome.
 
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